Lyrica is indicated to treat fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles in adult patients. Lyrica is also indicated to treat seizures in patients with epilepsy.
Lyrica is a prescription medicine approved by the US Food and Drug Administration (FDA) and is used in adults to manage fibromyalgia (chronic pain all over your body), diabetic nerve pain, or pain associated with diabetic peripheral neuropathy (pain in the feet and hands from damaged nerves caused by diabetes), spinal cord injury nerve pain, and pain after shingles. In addition, it is used together with other seizure medicines to treat partial onset seizures in patients 1 month of age and older with epilepsy. Pregabalin is approved as a treatment to supplement the effects of another drug for partial-onset seizures. It can be used with other antiseizure medications such as carbamazepine (CARBATROL, TEGRETOL), lamotrigene (LAMICTAL), phenytoin (DILANTIN) or valproic acid to increase their overall effectiveness. Many patients who experience partial-onset seizures have an inadequate response to available drugs. Up to 12% of adults facing this condition may become seizure-free with pregabalin.
Lyrica isn't a narcotic, but it does produce similar effects. People with a history of alcohol or drug abuse are at a greater risk of abusing Lyrica. Additionally, researchers have received reports of physical and/or psychological dependence. Every year, thousands of people abuse prescription medications at least once, according to statistics from the National Institute on Drug Abuse. Understanding how your medications work and taking them according to your doctor's instructions are two critical steps in minimizing the risk of abusing Lyrica.
How much does Lyrica cost? Without insurance, brand name Lyrica costs between $400 to $700 per month, depending on dosage and quantity. Retail prices of the Pregabalin (generic Lyrica) range between $100 and $300 per month.
Studies do show that Lyrica produces psychoactive effects, such as euphoria, that are similar to those produced by other controlled substances. Reports have surfaced of patients abusing the medication. Research also suggests that although Lyrica is considered a controlled substance, it could serve as a viable substitute for medications that put patients at higher risk of abuse and addiction, including benzodiazepines and opioids.
Is Lyrica an antidepressant? Lyrica is not an antidepressant. Be sure to tell your doctor about all the medicines you are taking. Is Lyrica a narcotic? Lyrica is not a narcotic. But if you have had a drug or alcohol problem, you may be more likely to misuse Lyrica.
25 mg - White hard gelatin capsule, marked "Pfizer PGN 25" with black ink.
75mg - White and orange hard gelatin capsule, marked "Pfizer PGN 75" with black ink.
150mg - White hard gelatin capsule, marked "Pfizer PGN 150" with black ink.
300mg - White and orange hard gelatin capsule, marked "Pfizer PGN 300" with black ink.
25 mg capsules - 25 mg pregabalin
75 mg capsules - 75 mg pregabalin
150 mg capsules - 150 mg pregabalin
300 mg capsules - 300 mg pregabalin
It also contains:
Generic Lyrica is available with a prescription in the U.S. in eight strengths (25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, and 300 mg).
Is generic Lyrica more affordable? In most cases, cost-savings can be significant if you select a generic option (pregabalin) over a brand name for your prescription.
Are brand name and generic drugs both equally safe? In most cases you can feel confident selecting a generic option at the pharmacy. The FDA requires that generic drugs meet rigorous scientific and quality standards. Generic drugs must be as high in quality as brand name drugs. Generic drugs contain the same active ingredients as their brand name counterparts and work the same way. So you can buy generic Lyrica (pregabalin) online. They have the same risks and the same benefits as the brand name drugs.
How to buy Lyrica anonymously? Interest to pregabalin can be explained by the fact that the drug is purchased without prescription and used in nonmedical purposes.
Can i buy Pregabalin without a doctor's prescription? Following concerns about misuse of these drugs, the law changed so that in some countries it is now illegal to possess gabapentin or pregabalin without a prescription.
Pregabalin works by changing the way in which nerves send messages to your brain. When something presses on a nerve, or a nerve doesn't work properly in some way, the nerve can send false messages to your brain. The brain thinks that a part of your body is being hurt when it is not. This makes you actually feel pain. By altering the way nerves work, pregabalin may reduce your pain. This prescription medication, known as pregabalin in its generic form, isn't a narcotic. It's a gamma-amino-butyric acid (GABA) analog that's roughly three to four times more potent than its predecessor, gabapentin, according to research published by the U.S. National Library of Medicine. It works by powerfully binding to components of the nervous system to soothe damaged or overactive nerves. Side effects like dizziness and sleepiness could increase if you take Lyrica with alcohol or narcotic medications. Although more research on Lyrica withdrawal is needed to fully understand the risks, patients who stop taking it without tapering the dosage over time could experience various withdrawal symptoms.
Patients taking pregabalin should start with the lowest recommended dose. If necessary, the prescribing physician should increase the dose gradually. People with kidney problems or who are on dialysis may need dose adjustments. Lyrica is believed to work on damaged nerves, or calm overactive nerves, depending on your condition. It is unknown exactly how Lyrica works in the body. However, certain studies suggest that Lyrica reduces "extra" electrical signals sent out by damaged nerves in the body. The implication of these studies in humans is not known.
Isn't Lyrica (Pregabalin) for treating epilepsy? Yes, pregabalin is used for treating epilepsy by "calming down nerves". Research has shown that pregabalin by a "similar process" is also effective in helping to relieve certain types of pain. Lyrica (Pregabalin) has three approved uses for pain:
You should notice that your pain starts to improve over one to two weeks after starting pregabalin, but it may take longer in some people. However, some people feel benefit straight away. Your treatment will be reviewed when you next see the doctor or nurse. If pregabalin is helpful, you can continue taking it and your treatment will be reviewed regularly. There is no possibility of you becoming addicted to the tablets. It is also important that you continue to take your regular painkiller, unless you have been advised to stop taking these by your doctor.
Take Lyrica every day as prescribed by your doctor. Here are a few ways to help make sure you take Lyrica the right way:
Lyrica may cause serious, even life-threatening, allergic reactions. Stop taking Lyrica and call your doctor right away if you have any signs of a serious allergic reaction. Some signs are swelling of your face, mouth, lips, gums, tongue, throat or neck or if you have any trouble breathing, or have a rash, hives or blisters.
Lyrica is available in multiple strengths. Your doctor can adjust your dose to help you get the most from treatment. So it's important to discuss your progress and any side effects you may feel with your doctor, especially in the first few weeks. Your healthcare provider may change your dose. Do not change your dose without talking to your doctor.
It may take time for Lyrica to work. In clinical studies in fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles, some patients experienced a decrease in pain in as early as 1 week. For others it took longer. If you are not feeling the pain relief you expect, there may be things your doctor can do to help. Talk to your doctor to find out if adjusting your dose may be right for you.
The 2 most common side effects of Lyrica are dizziness and sleepiness. Other side effects in these studies include dry mouth, swelling of the hands and feet, blurred vision, weight gain, trouble concentrating. These side effects were generally mild to moderate. Lyrica may also cause serious, even life-threatening, allergic reactions. Stop taking Lyrica and call your doctor right away if you have any signs of a serious allergic reaction. Some signs are swelling of your face, mouth, lips, gums, tongue, throat or neck or if you have any trouble breathing, or have a rash, hives or blisters. If you stop taking Lyrica suddenly, you may have headaches, nausea, diarrhea, or trouble sleeping. If you have epilepsy and you stop taking Lyrica suddenly, you may have seizures more often. If you and your doctor do decide you need to stop taking Lyrica, he or she will help you stop gradually.
It's important to give your doctor your full medical history. This will make sure you have the best possible experience with Lyrica. Before taking Lyrica, tell your doctor about all your medical conditions, including if you:
Tell your doctor about all the medicines, vitamins, or herbal supplements you take, especially medicines that make you sleepy or any medicines mentioned below:
Any angiotensin-converting enzyme (ACE) inhibitor, used to treat many conditions such as high blood pressure: Taking this with Lyrica may increase the chance for swelling and hives.
Avandia (rosiglitazone), Avandamet (contains rosiglitazone and metformin), or Actos (pioglitazone) used for diabetes: Taking these with Lyrica may increase the chance of weight gain or swelling of your hands or feet.
Any opioids (such as oxycodone), tranquilizers, or medicines for anxiety (such as lorazepam): Taking these with Lyrica may increase the chance for dizziness and sleepiness.
Opioids (narcotic) pain medicines: Taking Lyrica in combination with these medications may reduce central nervous system activity that could lead to death.
Know the medicines you take. Keep a list of them with you to show your healthcare provider and pharmacist each time you get a new medicine. Do not start a new medicine without talking with your doctor. Do not drink alcohol while taking Lyrica. Lyrica and alcohol can affect each other and increase side effects such as sleepiness and dizziness.
Lyrica is not for everyone. Lyrica may cause serious, even life-threatening, allergic reactions. Stop taking Lyrica and call your doctor right away if you have any signs of a serious allergic reaction. Some signs are swelling of your face, mouth, lips, gums, tongue, throat or neck, if you have any trouble breathing, or have a rash, hives, or blisters. Drugs used to treat seizures increase the risk of suicidal thoughts or behavior. Lyrica may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Patients, family members, or caregivers should call the doctor right away if they notice suicidal thoughts or actions, thoughts of self-harm, or any unusual changes in mood or behavior. These changes may include new or worsening depression, anxiety, restlessness, trouble sleeping, panic attacks, anger, irritability, agitation, aggression, dangerous impulses or violence, or extreme increases in activity or talking. If you have suicidal thoughts or actions, do not stop Lyrica without first talking to your doctor.
Serious breathing problems can occur when Lyrica is taken with other medicines that can cause severe sleepiness or decreased awareness, or when it is taken by someone who already has breathing problems. Watch for increased sleepiness or decreased breathing when starting Lyrica or when the dose is increased. Get help right away if breathing problems occur. Lyrica may cause swelling of your hands, legs, and feet, which can be serious for people with heart problems. Lyrica may cause dizziness and sleepiness. You should not drive or work with machines until you know how Lyrica affects you. Also, tell your doctor right away about muscle pain or problems along with feeling sick and feverish, or any changes in your eyesight, including blurry vision or if you have any kidney problems or get dialysis.
Tell your doctor immediately if you are taking opioid painkillers (such as oxycodone), or medicines for anxiety (such as lorazepam) or insomnia (such as zolpidem). You may have a higher chance for dizziness, sleepiness or serious breathing problems if these medicines are taken with Lyrica. Taking Lyrica with opioid pain medicines may lead to death. Some of the most common side effects of Lyrica are dizziness, blurry vision, weight gain, sleepiness, trouble concentrating, swelling of your hands and feet, dry mouth, and feeling “high.” If you have diabetes, tell your doctor about any skin sores.
You may have a higher chance for swelling and hives if you are also taking angiotensin-converting enzyme (ACE) inhibitors, so tell your doctor if you are taking these medications. You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking certain diabetes medicines. Do not drink alcohol while on Lyrica. You may have a higher chance for dizziness and sleepiness if you take Lyrica with alcohol, narcotic pain medicines, or medicines for anxiety.
Before you start Lyrica, tell your doctor if you are planning to father a child, if you are pregnant, or plan to become pregnant. Breastfeeding is not recommended while taking Lyrica. If you have had a drug or alcohol problem, you may be more likely to misuse Lyrica. In studies, a specific type of blood vessel tumor was seen in mice. The meaning of these findings in humans is not known. Do not stop taking Lyrica without talking to your doctor. If you stop suddenly, you may have headaches, nausea, diarrhea, trouble sleeping, increased sweating, or you may feel anxious. If you have epilepsy, you may have seizures more often.
Everyone is unique and may respond to Lyrica differently. Lyrica is available in multiple strengths. Your doctor can adjust your dose to help you get the most from treatment. So it's important to discuss your progress and any side effects you may feel with your doctor, especially in the first few weeks. The maximum recommended dose of Lyrica is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability. The approved doses for the different indications of Lyrica are as follows:
Your doctor may make adjustments according to your needs. If you have problems with kidney function, your doctor may prescribe a lower dose of Lyrica. Patients who do not experience sufficient pain relief with 300 mg/day may be further increased to 450 mg/day. Patients who do not experience sufficient pain relief following 2 to 3 weeks of treatment with 300 mg per day, and who are able to tolerate Lyrica, may be treated with up to 600 mg per day.Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg per day, and who are able to tolerate Lyrica, may be treated with up to 600 mg per day.
What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
May not be suitable for some people including those with cardiovascular disease or kidney disease. In some countries, restrictions have been placed on the prescribing of pregabalin because of its potential for misuse. Experts rate the addiction potential of pregabalin as higher than that of gabapentin because it is more rapidly absorbed and has a faster onset of action.
Pregabalin may be taken with or without food. May interfere with your ability to drive or operate machinery or perform other hazardous tasks. Alcohol may enhance this effect. Pregabalin is used in the treatment of nerve pain and also to prevent seizures. Drowsiness or dizziness are common side effects, and it has the potential to be misused.